PF-07284892

SI-7380

PF-07284892, >98% (HPLC)

CAS No. : [2498597-94-5]

Synonyms : ARRY-558

IUPAC Name : (S)-1'-(6-((2-Amino-3-chloropyridin-4-yl)thio)-1,2,4-triazin-3-yl)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑07284892 is a potent, orally active inhibitor of SHP2 with an IC₅₀ of 21 nM. It downregulates pERK expression, demonstrating robust inhibition of MAPK/ERK signaling and making it a valuable tool for probing SHP2‑driven tumor biology.

References : Abdayem P. et al.: Clin. Adv. Hematol Oncol., 20(11), 662-672, 2022; Drilon A. et al.: Cancer Discov., 13(8), 1789-1801, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.