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PF-3644022

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SI-6370

PF-3644022, >98% (HPLC)

CAS No. : [1276121-88-0]

IUPAC Name : (R)-10-Methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one

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Chemical Properites
Mol. Formula :
C21H18N4OS
Mol. Weight :
374.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PF‑3644022 selectively targets MK2 with low‑nanomolar potency and also inhibits MK3 and PRAK. By blocking MK2‑mediated cytokine regulation, it strongly reduces TNFα production and exhibits pronounced anti‑inflammatory activity.

References : Mourey R. J. et al.: J. Pharmacol. Exp. Ther., 333(3), 797-807, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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