PF-431396

SI-6444

PF-431396, >98% (HPLC)

CAS No. : [717906-29-1]

IUPAC Name : N-Methyl-N-(2-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑431396 potently inhibits FAK (IC₅₀ = 2 nM) and PYK2 (IC₅₀ = 11 nM) and is orally active, enabling effective modulation of adhesion‑mediated signaling pathways relevant to tumor cell motility, survival, and metastasis.

References : Han S. et al.: J. Biol. Chem., 284(19), 13193–13201, 2009; Ciceri P. et al.: Nat. Chem. Biol., 2014; Tse K. W. et al.: J. Biol. Chem., 284(34), 22865-77, 2009; Buckbinder L. et al.: Proc. Natl. Acad. Sci. U S A., 104(25), 10619-24, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.