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PHA-680632

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SI-7202

PHA-680632, >98% (HPLC)

CAS No. : [398493-79-3]

IUPAC Name : N-(2,6-Diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

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Chemical Properites
Mol. Formula :
C28H35N7O2
Mol. Weight :
501.63
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PHA‑680632 selectively targets Aurora A, B, and C kinases with IC50 values of 27/135/120 nM, respectively, supporting its use in probing Aurora‑mediated cell‑cycle progression and mitotic control.

References : Soncini C. et al.: Clin. Cancer Res., 12(13), 4080-9, 2006; Tao Y. et al.: Br. J. Cancer. 97(12), 1664-72, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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