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PHA-767491

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SI-6388

PHA-767491, >98% (HPLC)

CAS No. : [845714-00-3]

Synonyms : CAY-10572

IUPAC Name : 2-(Pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C12H11N3O
Mol. Weight :
213.24
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PHA‑767491 inhibits Cdc7 and CDK9 with low‑nanomolar potency (IC50 = 10/34 nM), providing a useful tool for probing pathways that couple replication initiation with transcriptional control.

References : Sasi N. K. et al.: PLoS One., 9(11), e113300, 2014; Li W. et al.: Curr. Cancer Drug Targets., 15(3), 196-204, 2015; Erbayraktar Z. et al.: Cancer Cell Int. 16, 88, 2016; Montagnoli A. et al.: Nat. Chem. Biol., 4(6), 357-65, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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