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Phenoxybenzamine-d5 hydrochloride

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SL-6724

Phenoxybenzamine-d5 hydrochloride, >98% (HPLC)

Isotopic Purity : 99 atom % D

CAS No. : [1329838-45-0]

IUPAC Name : N-Benzyl-N-(2-chloroethyl)-1-(phenoxy-d5)propan-2-amine hydrochloride

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Chemical Properites
Mol. Formula :
C18H17D5ClNO . HCl
Mol. Weight :
345.32
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Phenoxybenzamine-d5 HCl is a deuterium labelled version of Phenoxybenzamine, which is a selective antagonist of both α-adrenoceptor and calmodulin. It is commonly used for the treatment of hypertension and heavy sweating due to a certain tumor of the adrenal glands (pheochromocytoma).

References : Lenox R. H. et al.: Mol Pharmacol., 27(1),1-9,1985; Byon H. J. et al.: Int. J. Med Sci., 14(2),143-149, 2017; Lin X. B. et al.: Tumour Biol., 37(3), 2901-8, 2016; Rau T. F. et al.: Int. J. Mol Sci., 15(1), 1402-17, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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