PI3Kalpha H1047R inhibitor 17

SI-7589

PI3Kα H1047R inhibitor 17, >98% (HPLC)

CAS No. : [25030-26-6]

IUPAC Name : (R)-2-((1-(3-Cyano-2-(4,4-difluoropiperidin-1-yl)-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This selectively targets the PI3Kα H1047R mutant with low‑nanomolar potency (IC₅₀= 1 nM, pAKT inhibition) and shows no activity toward PI3Kα WT. This high degree of selectivity supports its use in studying mutant‑specific PI3Kα signaling pathways.

References : Ketcham M. J. et al.: J. Med. Chem., 67(6), 4936-4949, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.