PI3Kalpha inhibitor

SI-7143

PI3Kα inhibitor, >98% (HPLC)

IUPAC Name : 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)benzofuran-2-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent, selective, and long‑acting PI3Kα inhibitor with IC₅₀ = 4.4 nM. It shows excellent selectivity across homologous PI3K isoforms and a 370‑kinase panel, and features high stability (t_1/2 > 10 h) and exceptional oral bioavailability (130%). In vivo, it demonstrates strong antigastric cancer efficacy when combined with taxol, making it a promising PI3Kα‑targeted agent for cancer research.

References : Hou Y. et al.: J. Med. Chem., 65(14), 9873-9892, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.