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Pifusertib hydrochloride

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SI-7089

Pifusertib hydrochloride, >98% (HPLC)

CAS No. : [2930090-28-9]

Synonyms : TAS-117 hydrochloride

IUPAC Name : (1s,3s)-3-Amino-1-methyl-3-(4-(3-phenyl-5H-imidazo[1,2-c]pyrido[2,3-e][1,3]oxazin-2-yl)phenyl)cyclobutan-1-ol hydrochloride

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5MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C26H24N4O2 • HCl
Mol. Weight :
460.96
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Pifusertib hydrochloride selectively inhibits Akt isoforms with low‑nanomolar potency and amplifies ER‑stress responses induced by proteasome blockade. It exhibits robust anti‑myeloma activity and triggers both apoptosis and autophagy.

References : Mimura N. et al.: Cancer Res., 74(16), 4458-4469, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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