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Pioglitazone N-oxide

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SL-4357

Pioglitazone N-oxide, >98%

CAS No. : [145350-09-0]

IUPAC Name : 2-(2-(4-((2,4-Dioxothiazolidin-5-yl)methyl)phenoxy)ethyl)-5-ethylpyridine 1-oxide

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Chemical Properites
Mol. Formula :
C19H20N2O4S
Mol. Weight :
372.44
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an oxidative metabolite of Pioglitazone (Pioglitazone N-oxide), which is a selective peroxisome proliferator-activated receptor-gamma (PPARγ) agonist, used to treat diabetes.

References : Jaakkola T. et al.: Basic Clin Pharmacol Toxicol., 99(1), 44-51, 2006; Shiomi T. et al.: Circulation. 106(24), 3126-3132, 2002; Dehmer T. et al.: J Neurochem, 88(2), 494-501, 2004; Breidert T. et al.: J. Neurochem 82(3), 615-624, 2002; Heneka M. T. et al.: Brain, 128(Pt 6), 1442-1453, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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