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Pipamperone

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SL-9778

Pipamperone, >98%

CAS No. : [1893-33-0]

Synonyms : Floropipamide; McN-JR 3345; R-3345

IUPAC Name : 1'-(4-(4-Fluorophenyl)-4-oxobutyl)-[1,4'-bipiperidine]-4'-carboxamide

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Chemical Properites
Mol. Formula :
C21H30FN3O2
Mol. Weight :
375.49
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : Pipamperone is a butyrophenone derivative that serves as a high-affinity antagonist for the 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0), while exhibiting low-affinity antagonism at the D2 receptor (pKi=6.7). By modulating neurotransmitter activity, pipamperone demonstrates antipsychotic effects. It is utilised in research focused on mental health conditions, including autism-related behavioural disorders and Alzheimer's disease.

References : Oekelen D. V. et al.: Eur. J. Pharmacol., 425(1), 21-32, 2001; Petrosino B. et al.: European Psychiatry 33(S1), S549-S549, 2016; Kamp D. et al.: Ther Adv Psychopharmacol., 6(1), 55-57, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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