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PK-68

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SI-8007

PK-68, >98% (HPLC)

CAS No. : [2173556-69-7]

IUPAC Name : Cyclohexyl 2-(5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)acetate

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Chemical Properites
Mol. Formula :
C23H25N3O3S
Mol. Weight :
423.53
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PK-68 is an orally active type II RIPK1 inhibitor with nanomolar potency (~90 nM) and clear inhibition of RIPK1‑driven necroptosis. It provides strong protection in TNF‑induced SIRS models and serves as a valuable tool for investigating inflammatory pathology and metastatic processes.

References : Hou J. et al.: Cell. Death. Dis., 10(7), 493, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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