PLX 4720-d7

SI-5836

PLX 4720-d₇, >98% (HPLC)

Isotopic Purity : 98 atom % D

CAS No. : [1304096-50-1]

IUPAC Name : N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide-d₇

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PLX4720-d₇ is a deuterium labelled version an analog of PLX4720, which is a potent and selective inhibitor of B-RafV600E with IC₅₀ of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.

References : Tsai J. et al.: Proc Natl Acad Sci U S A, 105(8), 3041-3046, 2008; Paraiso K. H. et al.: Cancer Res., 71(7), 2750-2760, 2011; Nucera C. et al.: Proc Natl Acad Sci U S A 107(23), 10649-10654, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.