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Polmacoxib-d6

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Polmacoxib-d6, >98%

Related CAS No. : [301692-76-2] of the unlabelled compound

Synonyms : CG-100649-d6

IUPAC Name : 4-(4-(3-Fluorophenyl)-2,2-bis(methyl-d3)-5-oxo-2,5-dihydrofuran-3-yl)benzenesulfonamide

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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C18H10D6FNO4S
Mol. Weight :
367.42
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Polmacoxib, which is an orally administered nonsteroidal anti-inflammatory drug (NSAID) that acts as a dual inhibitor of COX-2 and carbonic anhydrase. It is indicated for managing pain and inflammation related to osteoarthritis of the hip and knee. Additionally, Polmacoxib has been shown to inhibit colorectal adenoma and tumor growth in mouse models.

References : Kim S. H. et al.: Invest New Drugs 32(6), 1105-1112, 2014; Flick C. A. et al.: J. Med. Chem., 60(15), 6480-6515, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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