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Pomalidomide-propargyl

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SL-11260

Pomalidomide-propargyl, >98%

CAS No. : [2154342-25-1]

IUPAC Name : 2-(2,6-Dioxopiperidin-3-yl)-4-(prop-2-yn-1-ylamino)isoindoline-1,3-dione

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C16H13N3O4
Mol. Weight :
311.3
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Pomalidomide-propargyl contains an E3 ligand along with a terminal alkyl group designed for click conjugation. This compound is suitable for attaching to target proteins, facilitating PROTAC applications.

References : Zhu Y. X. et al.: Leuk Lymphoma, 54(4), 683-7, 2013; Hernandez-Ilizaliturri F. et al.: Clin Cancer Res., 11(16), 5984-92., 2005; Schafer P. H. et al.: J. Pharmacol Exp Ther. 305(3), 1222-32, 2003; Li Z. et al.: PLoS One, 8(8), e71754, 2013; Lu J. et al.: Chem Biol., 22(6), 755-63, 2015; Liu D. et al.: Gen Comp Endocrinol., 228, 1-8, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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