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Posaconazole (3R,5S) isomer intermediate

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Posaconazole (3R,5S) isomer intermediate, >98%

CAS No. : [2423024-27-3]

IUPAC Name : ((3R,5S)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-chlorobenzenesulfonate

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Chemical Properites
Mol. Formula :
C20H18ClF2N3O4S
Mol. Weight :
469.89
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the synthesis of Posaconazole related analogs. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.

References : Benaim G. et al.: J. Med. Chem., 49(3), 892-9, 2006; Sabatelli F. et al.: Antimicrob Agents Chemother., 50(6), 2009-15, 2006; Sansone-Parsons A. et al.: Antimicrob Agents Chemother., 50(5), 1881-3, 2006; Veiga-Santos P. et al.: Int. J. Antimicrob Agents., 40(1), 61-71, 2012; Sun Q. N. et al.: Antimicrob Agents Chemother., 46(7), 2310-2, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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