PP-001

SI-6532

PP-001, >98% (HPLC)

CAS No. : [717142-73-9]

Synonyms : KIO‑100

IUPAC Name : 3-((2,3,5,6-Tetrafluoro-3'-(trifluoromethoxy)-[1,1'-biphenyl]-4-yl)carbamoyl)thiophene-2-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PP-001 selectively inhibits DHODH with sub‑nanomolar potency (IC₅₀ < 4 nM), making it ~150 times more potent than leflunomide. Its pharmacological profile supports its use in probing DHODH‑regulated immune and metabolic processes.

References : Diedrichs-Möhring M. et al.: J. Neuroinflammation, 15(1), 54, 2018; Thurau S. et al.: Front Med. (Lausanne)., 9, 1023224, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.