PPARalpha/delta dual agonist

SI-7984

PPARα/δ dual agonist, >98% (HPLC)

IUPAC Name : 2-(4-((2,5-Dioxo-3-(4-(trifluoromethyl)phenyl)imidazolidin-1-yl)methyl)-2,6-dimethylphenoxy)-2-methylpropanoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a hydantoin‑based PPARα/δ dual agonist with subnanomolar potency (PPARα EC₅₀ = 0.7 nM; PPARδ EC₅₀ = 0.4 nM) and excellent nuclear‑receptor selectivity. It shows strong PK, a good safety profile, and delivers potent anti‑cholestatic and antifibrotic activity in preclinical CLD models at very low doses (0.03–0.1 mg/kg). Overall, it is a promising therapeutic candidate for cholestatic liver diseases and hepatic fibrosis.

References : Feng Z. et al.: J. Med. Chem., 66(11), 7331-7354, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.