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Pretomanid

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SI-4058

Pretomanid, >98% (HPLC)

CAS No. : [187235-37-6]

MDL No. : MFCD06809939

Synonyms : PA-824

IUPAC Name : (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

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Chemical Properites
Mol. Formula :
C14H12F3N3O5
Mol. Weight :
359.26
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Pretomanid is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid; exhibits bactericidal activity against both replicating and static M. tuberculosis (MIC: 0.015-0.25 ug/mL); shows potent bactericidal activity against MDR M. tuberculosis and promising oral activity in animal infection models.

References : Palmer D. B. et al.: J. Med. Chem., 58(7), 3036-3059, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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