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PRMT5-IN-15

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SI-6515

PRMT5-IN-15, >98% (HPLC)

CAS No. : [2410637-87-3]

IUPAC Name : (1S,2R,3aR,4S,6aR)-4-((2-Amino-3,5-difluoroquinolin-7-yl)methyl)-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol

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Chemical Properites
Mol. Formula :
C24H23F3N6O2
Mol. Weight :
484.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PRMT5‑IN‑15 potently inhibits PRMT5 with an IC50 of 0.84 nM, enabling robust suppression of PRMT5‑mediated symmetric arginine dimethylation. It is well suited for mechanistic studies of PRMT5‑regulated cellular pathways.

References : Quiroz R. V. et al.: J. Med. Chem., 64(7), 3911-3939, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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