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PRMT5-IN-19

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SI-7073

PRMT5-IN-19, >98% (HPLC)

CAS No. : [2783961-86-2]

IUPAC Name : (S)-6-(4-(1-Phenylethoxy)phenyl)-4-(1,2,3,6-tetrahydropyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine

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Chemical Properites
Mol. Formula :
C25H24N4O
Mol. Weight :
396.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PRMT5‑IN‑19 is a selective, orally active PRMT5 inhibitor (IC50 = 23.9 nM biochemical; 47 nM AlphaLISA) that blocks SAM‑pocket methyltransferase activity with strong selectivity over other PRMTs. It suppresses cancer cell proliferation by inducing apoptosis and serves as a useful tool compound for PRMT5‑related cancer research.

References : Rong D. et al.: J. Med. Chem., 65(11), 7854−7875, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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