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Progesterone-d9

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Progesterone-d9, >98% (HPLC)

Isotopic Purity : 98 atom % D

CAS No. : [15775-74-3]

Synonyms : Pregn-4-ene-3,20-dione-d9

IUPAC Name : (8S,9S,10R,13S,14S,17S)-17-(Acetyl-d3)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one-d6

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Chemical Properites
Mol. Formula :
C21H21D9O2
Mol. Weight :
323.52
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Progesterone-d9 is a deuterium labelled version of Progesterone, which is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

References : Owen G. I. et al.: J. Biol Chem., 273(17), 10696-10701, 1998; Joshi P. A. et al.: Nature, 465(7299), 803-807, 2010; Bitran D. et al.: Pharmacol Biochem Behav., 45(2), 423-428, 1993; Carroll J. C. et al.: J. Neurosci., 27(48), 13357-13365, 2007; Roof R. L. et al.: Exp Neurol., 129(1), 64-69, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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