Proguanil-d4 hydrochloride

SL-6240

Proguanil-d₄ hydrochloride, >98% (HPLC)

Isotopic Purity : 98 atom % D

CAS No. : [1189671-34-8]

Synonyms : Chloroguanide-d₄ hydrochloride; Chlorguanide-d₄ hydrochloride

IUPAC Name : N1-(4-Chlorophenyl-d₄)-N3-(propan-2-yl)imidodicarbonimidic diamide hydrochloride

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Proguanil-d₄ HCl is a deuterium labelled version of Proguanil, which is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.

References : Srivastava I. K. et al.: Antimicrob Agents Chemother., 43(6), 1334-9, 1999;Lochner M. et al.: J. Pharmacol Exp Ther., 351(3), 674-84, 2004; Stephen A. O. et al.: J. Toxicol Sci., 36(5), 587-99, 2011; Iguchi A. et al.: Vet. Parasitol., 197(3-4), 527-33, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.