PRT-062607

SI-6316

PRT-062607, >98% (HPLC)

CAS No. : [1370261-96-3]

Synonyms : PRT-2607; BIIB-057; P505-15

IUPAC Name : 4-((3-(2H-1,2,3-Triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PRT-062607 is a highly selective, low‑nanomolar Syk inhibitor that blocks BCR signaling, basophil degranulation, and microglial activation. It induces caspase‑dependent microglial apoptosis and demonstrates efficacy in models of tumor growth, neuropathic pain, and neuronal injury. Its broad activity across immune and neuroinflammatory pathways supports its use in studies of RA, CLL, NHL, neurodegeneration, and pain biology.

References : Coffey G. et al.: J. Pharmacol. Exp. Ther., 340(2), 350-359, 2012; Spurgeon S. E. et al.: J. Pharmacol. Exp. Ther., 344(2), 378-387, 2013; Birkle T. J. Y. et al.: Front Aging Neurosci., 15, 1120952, 2023; Ghazisaeidi S. et al.: Br. J. Pharmacol., 180(21), 2822-2836, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.