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PS-1145

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SI-5143

PS-1145, >98% (HPLC)

CAS No. : [431898-65-6]

MDL No. : MFCD18089825

IUPAC Name : N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide

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Chemical Properites
Mol. Formula :
C17H11ClN4O
Mol. Weight :
322.75
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.

References : Hideshima T. et al.: J. Biol Chem., 277(19), 16639-47, 2002; Vodanovic-Jankovic S. et al.: Blood 107(2), 827-34, 2006; Oh-I S. et al.: Am. J. Physiol Endocrinol Metab., 299(1), E47-53, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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