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Quizartinib dihydrochloride

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SI-6938

Quizartinib dihydrochloride, >98% (HPLC)

CAS No. : [1132827-21-4]

Synonyms : AC-220 dihydrochloride; AC-708 dihydrochloride

IUPAC Name : 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea dihydrochloride

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Chemical Properites
Mol. Formula :
C29H32N6O4S • 2HCl
Mol. Weight :
633.59
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Quizartinib dihydrochloride is a potent oral FLT3 inhibitor that blocks mutant FLT3/PDGFRA/KIT signaling and induces apoptosis in cancer cells.

References : Kampa-Schittenhelm K. M. et al.: Mol. Cancer, 12, 19, 2013; Cortes J. et al.: Lancet Oncol., 19(7), 889-903, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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