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(R)-2-Amino-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanol

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SL-4223

(R)-2-Amino-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethanol, >98%

CAS No. : [208925-08-0]

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Chemical Properites
Mol. Formula :
C12H17NO3
Mol. Weight :
223.27
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an advanced key intermediate in the preparation of Vilanterol and related analogs. Vilanterol is a selective long-acting β2 adrenoreceptor agonist (LABA), for the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

References : Slack R. J. et al.: J. Pharmacol Exp Ther., 344(1), 218-230, 2013. Calzetta L. et al.: Eur. J. Pharmacol., Jul 14, S0014-2999(17), 30470-3, 2017; Kempsford R. et al.: Pulm Pharmacol Ther., 26(2), 256-264; 2013; Harrell A. W. et al.: Drug Metab Dispos., 41(1), 89-100, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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