(R)-(4-(1-Cyclopropyl-1-(5-(1-(2-(dimethylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)ethyl)phenyl)boronic acid pinacol ester

SI-3773

(R)-(4-(1-Cyclopropyl-1-(5-(1-(2-(dimethylamino)-2-oxoethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)ethyl)phenyl)boronic acid pinacol ester, 97%

CAS No. : [1360552-43-7]

IUPAC Name : (R)-2-(4-(3-(1-Cyclopropyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)-N,N-dimethylacetamide

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Applications : This is an advanced key intermediate in the preparation of BI-665915 and related analogs, which is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor.

References : Takahashi H. et al.: J. Med. Chem., 58(4), 1669-1690, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.