R-547 mesylate

SI-7776

R-547 mesylate, >98% (HPLC)

CAS No. : [869369-26-6]

IUPAC Name : (4-Amino-2-((1-(methylsulfonyl)piperidin-4-yl)amino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone methanesulfonate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : R-547 mesylate selectively inhibits CDK1, CDK2, and CDK4 in an ATP‑competitive manner, with K_i values of 1–3 nM. Its potency and oral bioavailability support its use in studying CDK‑dependent mechanisms of proliferation and cell‑cycle control.

References : Chu X. J. et al.: J. Med. Chem., 49(22), 6549-60, 2006; Bayés M. et al.: Methods Find. Exp. Clin. Pharmacol., 29(6), 427-37, 2007; Martin F. et al.: BMC Syst. Biol., 31, 6:54, 2012; DePinto et al.: Mol. Cancer Ther., 5(11), 2644-58, 2006; Jones D. C. et al.: Bioorg. Med. Chem. Lett., 18(24), 6486-9, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.