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(R)-Acalabrutinib

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(R)-Acalabrutinib, >98%

CAS No. : [1952316-43-6]

IUPAC Name : (R)-4-(8-Amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

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Chemical Properites
Mol. Formula :
C26H23N7O2
Mol. Weight :
465.52
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : (R)-Acalabrutinib is the enantiomer of Acalabrutinib, which is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor. Acalabrutinib is used to treat a type of non-Hodgkin lymphoma known as mantle cell lymphoma.

References : Wu J. et al.: J. Hematol Oncol., 9, 21, 2016; Heather L. G. et al.: Cancer Res., 74(19 Supplement), 1744, 2014; Todd C. et al. Cancer Res., 75(15 Supplement), 25, 2015; Qin J. et al.: J. Immun., 43, 107-120, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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