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(R)-BAY-1238097

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SI-6176

(R)-BAY-1238097, >98% (HPLC)

CAS No. : [1564269-85-7]

IUPAC Name : (R)-7,8-Dimethoxy-N,4-dimethyl-1-(4-(4-methylpiperazin-1-yl)phenyl)-4,5-dihydro-3H-benzo[d][1,2]diazepine-3-carboxamide

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Chemical Properites
Mol. Formula :
C25H33N5O3
Mol. Weight :
451.57
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (R)-BAY-1238097 is the less active stereoisomer of BAY-1238097. The parent compound potently blocks BET binding to acetylated histones and inhibits proliferation in AML and MM models by suppressing c‑Myc levels and downstream gene expression.

References : Lejeune P. et al.: Cancer Research, 75(15), 884, 2011; Bernasconi E. et al.: Br. J. Haematol., 178(6), 936-948, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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