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(R)-Bemcentinib

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SI-6508

(R)-Bemcentinib, >98% (HPLC)

CAS No. : [1037624-76-2]

Synonyms : (R)-BGB-324; (R)-R-428

IUPAC Name : (R)-1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine

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Chemical Properites
Mol. Formula :
C30H34N8
Mol. Weight :
506.66
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (R)-Bemcentinib is the (R)‑isomer of Bemcentinib, a selective AXL inhibitor (IC50 = 14 nM) that blocks metastasis and improves survival.

References :
Sensi M. et al.: J. Invest. Dermatol., 131(12), 2448-57, 2011; Holland S. J. et al.: Cancer Res., 70(4), 1544-54, 2010; Lijnen H. R. et al.: J. Pharmacol. Exp. Ther., 337(2), 457-64, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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