(R)-MRT-199665

SI-7500

(R)-MRT-199665, >98% (HPLC)

IUPAC Name : (R)-7-(4-Hydroxy-2,3-dihydro-1H-inden-1-yl)-5,5-dimethyl-2-((3-(pyrrolidin-1-ylmethyl)phenyl)amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : (R)-MRT-199665 represents the enantiomeric form of MRT-199665, a potent ATP‑competitive inhibitor of MARK, SIK, and AMPK kinases. MRT-199665 blocks CRTC3‑S370 phosphorylation and triggers apoptosis in MEF2C‑activated AML cells, making the (R)-isomer a useful comparator for probing stereochemical contributions to kinase inhibition.

References : Clark K. et al.: Proc. Natl. Acad. Sci. U S A., 109(42), 16986-91, 2012; Brown FC. et al.: Cancer Discov., 8(4), 478-497, 2018; Hutchinson LD. et al.: Cell Death. Dis., 11(1), 49, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.