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(R)-Oxybutynin-d10 hydrochloride

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(R)-Oxybutynin-d10 hydrochloride, >98%

Related CAS No. : [1189190-67-7] of the free base compound

IUPAC Name : 4-(Bis(ethyl-d5)amino)but-2-yn-1-yl (R)-2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride

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Chemical Properites
Mol. Formula :
C22H21D10NO3 . HCl
Mol. Weight :
404.01
Appearance :
Off-white solid (hygroscopic)
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version (R)-enantiomer of Oxybutynin, which is a competitive antagonist of the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor. Oxybutynin is used to relieve urinary and bladder difficulties. (R)-Oxybutynin is the more pharmacologically active enantiomer, exhibiting greater antimuscarinic activity than (S)-Oxybutynin.

References : Lukkari E. et al.: Pharmacol Toxicol, 82(4), 161-166, 1998; Tonini M. et al.: J. Pharm Pharmacol, 39(2), 103-107, 1987; Comar J. F. et al.: Pharmacol Toxicol, 93(3), 147-152, 2003; Yoshida A. et al.: Life Sci, 87(5-6), 175-180, 2010; Guarneri L. et al.: Pharmacol Res, 24(3), 263-272, 1991.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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