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(R)-Pentoxifylline metabolite I

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SL-9737

(R)-Pentoxifylline metabolite I, >98%

CAS No. : [100324-81-0]

Synonyms : (R)-Lisofylline; (R)-Lisophylline

IUPAC Name : (R)-1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione

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Chemical Properites
Mol. Formula :
C13H20N4O3
Mol. Weight :
280.33
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : (R)-Pentoxifylline metabolite I, also known as (R)-M1, This is an enantiomer of Pentoxifylline metabolite I, one of several active metabolites of the drug Pentoxifylline. While the (S)-enantiomer (S-M1) is more abundant in the body, (R)-M1 is more potent in its effects on platelet aggregation and retinal blood flow.

References : Wyska E. et al.: Eur. J. Drug Metab Pharmacokinet. 41(4), 403-12, 2016; Hybertson B. M. et al.: J. Appl Physiol (1985) 82(1), 226-32, 1997; Bright J. J. et al.: J. Immunol.,161(12), 7015-22, 1998.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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