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(R)-Roscovitine

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SI-6391

(R)-Roscovitine, >98% (HPLC)

CAS No. : [186692-46-6]

Synonyms : Seliciclib; CYC-202

IUPAC Name : (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

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Chemical Properites
Mol. Formula :
C19H26N6O
Mol. Weight :
354.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : (R)-Roscovitine selectively inhibits CDK5, Cdc2, and CDK2 with sub‑micromolar potency and demonstrates oral bioavailability and BBB permeability. These properties make it a valuable tool compound for probing CDK‑dependent signaling in cancer and neurobiology.

References : Meijer L. et al.: Eur. J. Biochem., 243(1-2), 527-36, 1997; Bai X. et al.: Oncotarget, 2016; Gary C. et al.: Oncotarget., 2016; Menn B. et al.: PLoS One, 5(8), e12117, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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