(R,S)-Ivosidenib-d4

SL-9563

(R,S)-Ivosidenib-d₄, >98%

Related CAS No. : [2070009-31-1] of the unlabelled compound

IUPAC Name : (S)-N-((R)-1-(2-Chlorophenyl-3,4,5,6-d₄)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
10MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
25MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
50MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026

Applications : This is a deuterium labelled version less active diastereomer of Ivosidenib, which is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme. It exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib has the potential for AML therapy due to its acceptable safety profile and clinical activity.

References : Popovici-Muller J. et al.: ACS Med Chem Lett., 9(4), 300-305, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.