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rac-Cobimetinib

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SI-5523

rac-Cobimetinib, >98% (HPLC)

CAS No. : [934662-91-6]

MDL No. : MFCD25977160

Synonyms : rac-Cotellic; rac-GDC-0973; rac-RG7420

IUPAC Name : (3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

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Chemical Properites
Mol. Formula :
C21H21F3IN3O2
Mol. Weight :
531.31
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : rac-Cobimetinib is a recemic version of Cobimetinib, which is a potent and highly selective MEK1 inhibitor, for the potential treatment of cancer.

References : Flick C. A. et al.: J. Med. Chem., 60(15), 6480-6515, 2017; Hoeflich K. P. et al.: Cancer Res., 72(1), 210-9, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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