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rac-Roscovitine

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SI-6394

rac-Roscovitine, >98% (HPLC)

CAS No. : [186692-44-4]

Synonyms : rac-Seliciclib; rac-CYC-202

IUPAC Name : 2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol

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Chemical Properites
Mol. Formula :
C19H26N6O
Mol. Weight :
354.46
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : rac-Roscovitine selectively targets CDKs by competing with ATP at the catalytic site, leading to inhibition of CDK‑dependent phosphorylation and induction of apoptosis in cancer cells. Its mechanism supports applications in studying CDK‑related pathologies spanning oncology, neurology, cardiology, infectious disease, and inflammatory conditions.

References : Jorda R. et al.: J. Med. Chem., 54(8), 2980-93, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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