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Raltegravir EP impurity A

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Raltegravir EP impurity A, >98%

CAS No. : [518048-03-8]

Synonyms : Raltegravir impurity B

IUPAC Name : 2-(2-Aminopropan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

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Chemical Properites
Mol. Formula :
C16H19FN4O3
Mol. Weight :
334.35
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Raltegravir, which is a potent integrase (IN) inhibitor, can be used to treat HIV infection.

References : Hare S. et al.: Proc Natl Acad Sci U S A 107(46), 20057-62, 2010; Xu P. et al.: J. Neuroimmune Pharmacol., 12(4), 682-692, 2017; Hicks C. et al.: Clin Infect Dis., 48(7), 931-9, 2009; Moss D. M. et al.: Antimicrob Agents Chemother., 56(6), 3020-6, 2012; Hare S. et al.: Mol Pharmacol., 80(4), 565-72, 2011; Lewis M. G. et al.: Retrovirology, 7, 21, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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