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Ramatroban

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SI-5182

Ramatroban, >98% (HPLC)

CAS No. : [116649-85-5]

MDL No. : MFCD00887606

Synonyms : BAY u3405

IUPAC Name : 3-((3R)-3-((4-Fluorophenyl)sulfonamido)-1,2,3,4,4a,9a-hexahydro-9H-carbazol-9-yl)propanoic acid

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Chemical Properites
Mol. Formula :
C21H23FN2O4S
Mol. Weight :
418.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ramatroban is a thromboxane A2(TxA2) receptor antagonist with Ki value of 10 to 13 nM. It also antagonizes a newly identified PGD2 receptor, CRTh2 expressed on the inflammatory cells. It is indicated for the treatment of coronary artery disease. Ramatroban has also been used for the treatment of asthma.

References : Stearns B. A. et al.: Bioorg Med Chem Lett., 19(16), 4647-51, 2009; Sugimoto H. et al.: J. Pharmacol Exp Ther., 305(1), 347-52, 2003; Haba R. et al.: J. Neurosci., 34(7), 2514-23, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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