(rel)-PRT-062607

SI-6319

(rel)-PRT-062607, >98% (HPLC)

CAS No. : [1194954-52-3]

Synonyms : (rel)-P505-15; (rel)-PRT-2607; (rel)-BIIB-057

IUPAC Name : 4-((3-(2H-1,2,3-triazol-2-yl)phenyl)amino)-2-(((1R,2S)-2-aminocyclohexyl)amino)pyrimidine-5-carboxamide

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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : (rel)-PRT-062607 defines the relative configuration of the potent Syk inhibitor PRT-062607, which displays low‑nanomolar activity (IC₅₀ = 1–2 nM) and strong selectivity over kinases such as Fgr, Lyn, FAK, Pyk2, and Zap70 (>80‑fold). This configuration is relevant for structural and mechanistic studies of Syk inhibition.

References : Coffey G. et al.: J. Pharmacol. Exp. Ther., 340(2), 350-9, 2012; Spurgeon S. E. et al.: J. Pharmacol. Exp. Ther., 344(2), 378-87, 2013; Hoellenriegel J. et al.: Leukemia, 26(7), 1576-83, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.