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Reldesemtiv

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SI-6828

Reldesemtiv, >98% (HPLC)

CAS No. : [1345410-31-2]

Synonyms : CK-2127107

IUPAC Name : 1-(2-((((1r,3r)-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl)methyl)amino)pyrimidin-5-yl)-1H-pyrrole-3-carboxamide

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Chemical Properites
Mol. Formula :
C19H18F2N6O
Mol. Weight :
384.39
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Reldesemtiv selectively activates fast skeletal muscle troponin with an EC50 of 3.4 µM and is orally active. By augmenting fast skeletal myofibril function, it improves exercise capacity in heart‑failure models and serves as a valuable tool for studying skeletal‑muscle contractility.

References : Hwee DT, et al.: J. Pharmacol. Exp. Ther., 353(1), 159-68, 2015; Andrews JA, et al.: Muscle Nerve., 57(5), 729-734, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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