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Resmetirom

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Resmetirom, >98%

CAS No. : [920509-32-6]

Synonyms : MGL-3196; VIA-3196

IUPAC Name : 2-(3,5-Dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

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Chemical Properites
Mol. Formula :
C17H12Cl2N6O4
Mol. Weight :
435.22
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Resmetirom is a highly selective, orally bioavailable agonist of the thyroid hormone receptor β (THR-β), exhibiting an EC50 value of 0.21 μM. It can be used for the study of non-cirrhotic non-alcoholic steatohepatitis.

References : Kelly M. J. et al.: J. Med. Chem., 57(10), 3912-23, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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