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Resmetirom pyridazine aniline carbamide impurity

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Resmetirom pyridazine aniline carbamide impurity, >98%

CAS No. : [2987937-25-5]

IUPAC Name : 2-Amino-N-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-2-oxoacetohydrazonoyl cyanide

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Chemical Properites
Mol. Formula :
C16H14Cl2N6O3
Mol. Weight :
409.23
Appearance :
Orange solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Resmetirom, which is a highly selective, orally bioavailable agonist of the thyroid hormone receptor β (THR-β), exhibiting an EC50 value of 0.21 μM. Resmetirom can be used for the study of non-cirrhotic non-alcoholic steatohepatitis.

References : Kelly M. J. et al.: J. Med. Chem., 57(10), 3912-23, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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