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RGFP966

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SL-1645

RGFP966, >98%

CAS No. : [1357389-11-7]

MDL No. : MFCD26960954

Synonyms : (E/Z)-RGFP 966

IUPAC Name : (E)-N-(2-Amino-4-fluorophenyl)-3-(1-cinnamyl-1H-pyrazol-4-yl)acrylamide

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Chemical Properites
Mol. Formula :
C21H19FN4O
Mol. Weight :
362.40
Appearance :
Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : RGFP966 is a selective HDAC3 inhibitor with an IC50 of 80 nM and no effective inhibition of any other HDAC at concentrations up to 15 μM.

References : Malvaez M. et al.: Proc Natl Acad Sci U S A. 110(7), 2647-2652, 2013; Leus N. G. et al.: Biochem Pharmacol. 108, 58-74,2016; Jia H. et al.: PLoS One 11(3), e0152498,2016; Bieszczad K. M. et al.: J. Neurosci., 35(38), 13124-13132, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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