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Rineterkib hydrochloride

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SI-7874

Rineterkib hydrochloride, >98% (HPLC)

CAS No. : [1715025-34-5]

IUPAC Name : 4-(3-Amino-6-((1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-N-((S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl)-2-fluorobenzamide hydrochloride

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Chemical Properites
Mol. Formula :
C26H27BrF3N5O2 • HCl
Mol. Weight :
614.89
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Rineterkib hydrochloride is an orally active ERK1/2 inhibitor designed for disorders driven by activating MAPK‑pathway mutations. It demonstrates strong activity in KRAS‑ and BRAF‑mutant tumors, including NSCLC, pancreatic cancer, colorectal cancer, and ovarian cancer. Rineterkib hydrochloride also inhibits RAF, contributing to its broader pathway‑targeting profile.

References :
Song Y. et al.: Genes & Diseases, 10(1), 76-88, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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