RIPK1-IN-17

SI-7413

RIPK1-IN-17, >98% (HPLC)

CAS No. : [3033385-59-7]

IUPAC Name : N-(6-(4-Fluoro-3-(2-(3-(Trifluoromethoxy)phenyl)acetamido)phenyl)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : RIPK1‑IN‑17 is an orally active, selective RIPK1 inhibitor (Kd = 17 nM) that shows no meaningful inhibition of RIPK3. It specifically blocks necroptosis, not apoptosis, by suppressing RIPK1, RIPK3, and MLKL phosphorylation. In vivo, RIPK1‑IN‑17 protects mice from hypothermia and death in necroptosis‑driven inflammatory models, making it a useful tool compound for studying SIRS and other necroptosis‑related diseases.

References : Fang J-J. et al.: J. Med. Chem., 66(22), 15288-15308, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.