RIPK1-IN-19

SI-7488

RIPK1-IN-19, >98% (HPLC)

CAS No. : [2763831-43-0]

IUPAC Name : (S)-5-(2-(Cyclopropanecarboxamido)-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(1-(3-fluorophenyl)ethyl)-1-methyl-1H-indole-3-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This selectively inhibits RIPK1 with nanomolar potency (IC₅₀= 15 nM) and shows no obvious activity against other RIPK family kinases. It provides robust protection in TNFα‑driven SIRS and IMQ‑induced psoriasis models, making it a valuable tool for exploring RIPK1‑dependent inflammatory and immune pathways.

References : Zhang L. et al.: J. Med. Chem., 67(1), 754-773, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.