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Riviciclib

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SI-7120

Riviciclib, >98% (HPLC)

CAS No. : [920113-02-6]

Synonyms : P 276-00 free base

IUPAC Name : 2-(2-Chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one

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Chemical Properites
Mol. Formula :
C21H20ClNO5
Mol. Weight :
401.84
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Riviciclib is a potent CDK inhibitor that suppresses CDK9–cyclin T1, CDK4–cyclin D1, and CDK1–cyclin B with IC50 values of 20 nM, 63 nM, and 79 nM, respectively. It exhibits antitumor activity in cisplatin‑resistant cells.

References : Roskoski R. Jr. Pharmacol. Res., 107, 249-275, 2016; Joshi K. S. et al.: Mol. Cancer Ther., 6(3), 918-25, 2007; Joshi K. S. et al.: Mol. Cancer Ther., 6(3), 926-34, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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